The last time David Moyes reached into the depth of his squad for an away European match the Hammers came up well short of the mark with a tepid performance away to Olympiacos in Athens.
He'll be hoping for a much better performance tonight in Serbia as he is forced to again field a weaker side due to an outbreak of niggly injuries that keep Antonio, Bowen and Kudus out of the matchday squad.
Despite that, he has still been able to field a strong starting side with Divin Mubama starting up front. It's another big chance for the almost man that is Said Benrahma, with rumours of an end of season (or even January) exit growing.
Mubama is looking to nail down a new contract and will need to impress in what is probably his biggest test yet at the club. Similarly, Ben Johnson has been handed a start ahead of Thilo Kehrer and needs to remind Moyes that he has a significant contribution to make at full back or will likely exit in the near future.
Pablo Fornals has been a superb servant at the club but has slipped well down the pecking order and will relish the opportunity of a starting berth tonight.
The bench is pretty youthful but also includes Cornet and Ings as attacking options if needed.
A win would all but seal the group for Moyes' men before the final group fixture against Freiberg.
Kick off is 5.45
West Ham United: Fabiański, Johnson, Mavropanos, Aguerd, Cresswell, Fornals, Ward-Prowse, Souček, Paquetá, Benrahma, MubamaSubs: Areola (GK), Anang (GK), Emerson, Scarles, Kehrer, Zouma, Ogbonna, Orford, Coventry, Chesters, Cornet, Ings